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The human CD155 extracellular domain(s), consisting of amino acids 1-344, with an IgG-Fc tag linked to a N-terminal 10x-histidine sequence. CD155, also known as Poliovirus receptor (PVR), is a protein that in humans is encoded by the CD155 gene. It is a transmembrane protein that belongs to the immunoglobulin superfamily. CD155 is expressed on the surface of various normal tissues, including brain, placenta, lung, liver, kidney, and heart. It functions as a receptor for poliovirus, measles virus, and several other viruses that cause a disease in humans. Additionally, CD155 has an important role in the immune system, where it functions in the regulation of T cell activation and differentiation. Dysfunction of CD155 is associated with the pathology of many diseases, including viral infections, autoimmune disorders, and cancer.