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DNA polymerase theta (Pol θ) is involved in an end-joining pathway of DNA double-strand breaks. Over expression of Pol θ is found in many cancers, including stomach, colon, breast and lung cancers, and correlated with poorer patient survival. Because suppression of gene expression of Pol θ results in sensitivity of cells to ionizing radiation and some DSB-inducing drugs, Pol θ is a validated anti-cancer drug target.

VisitAurora Biolabs

7270 Trade Street, Suite 103
San Diego, CA 92121, USA

(858) 215-4510

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VisitAurora Biolabs

7270 Trade Street, Suite 103
San Diego, CA 92121, USA

(858) 215-4510